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Macular Centre

How does the Valeda LDS treatment work?

The Valeda Light delivery system is the first approved treatment for Dry Age-related Macular Degeneration

In macular degeneration the ageing process of the retina cells causes a loss of function and eventually cell death. It uses Photobiomodulation, to apply specific wavelengths to the eye to improve energy production within the cells. The multiwavelength approach works on various cellular mechanisms to improve macular function.

Each of the 3 wavelengths have specific purposes in the treatment of Macular degeneration.

  • Wavelength of 850nm drives electron transfer, stimulates metabolic activity and inhibits inflammation and cell death.
  • Wavelength of 660nm promotes O2 binding, stimulates metabolic activity and inhibits inflammation and cell death.
  • Wavelength of 590nm inhibits VEGF expression and promotes nitric oxide generation.

Early studies have shown improvements in:

  • Visual Acuity

  • Contrast Sensitivity

  • Reduction of central drusen volume

Image from Lumithera showing reduction of drusen at the Macular after 2 treatment courses 

More on the science from Lumithera:

The mechanism of photobiomodulation (PBM) at the cellular level has been ascribed to the activation of mitochondrial respiratory chain components resulting in stabilization of metabolic function and initiation of a signalling cascade, which promotes cellular proliferation and cytoprotection.

PBM works through the absorption of photons by photoacceptors in the targeted tissue. Once absorbed, secondary cellular effects include increases in energy production and changes in signalling modalities such as reactive oxygen species, nitric oxide and cellular calcium.  Cellular changes occur through activation of transcription factors leading to modulation in protein synthesis, proliferation and ultimately improved cell survival.

PBM is currently used in physiotherapy, arthritis, wound repair and sports medicine and is increasingly being recognised as a therapy for the treatment of serious, life-threatening disease states.

Mitochondria produce energy to sustain normal cellular function

Cytochrome C oxidase (CCO), a critical protein involved in regulation of mitochondrial activity, has been shown to be a key photoacceptor of light in the far red to near-infrared (NIR) spectral range. Oxidative stress and impaired mitochondrial function


Learn more about Macular Degeneration…